It is now 3:44 am and my pug and english bulldog are still restless, irritable and twitching. I, like many, decided to try a product that is less expensive than frontline for flea and tick prevention. This was a big mistake. I feel terrible. The symptoms are the same as most in the stories already posted. My bulldog scratched until he was bleeding. This was after bathing them once with their normal shampoo before I called the 800 number on the package and then two additional baths using Palmolive dish soap. I received the same response as well…my dogs may be having a possible reaction to the substance. This is crazy! DO NOT USE THIS PRODUCT!!!