After dosing my Kitty with Hartz UltraGuardplus she almost immediately showed symptoms. First she wildly ran around the house for fifteen minutes. Then hid in what I knew was her favorite hiding place. When I approached her, she hissed and attempted to bite me. With gloves I was able to catch her and rinse the applied area. She then sat and stared at me, her eyes were fully dialated dispite a bright light for the rest of the evening. I was lucky. I still have Kitty.