Our 10 month old healthy Shar-pei suddenly collapsed & became listless, we rushed her to the Emergency vet where she underwent a series of tests. She has since been diagnosed with Liver disease that the emergency vet & our vet state that the application of the flea & tick drops caused. She is at home now, taking antibiotics & a steroid to build up her liver. She appears to be doing much better but we will not know whether the damage is permanent or not for a few more weeks. A very eye-opening and expensive experience that should never have happened !!!